Course overview

Computational Neuroscience is a rapidly evolving field whose methods and techniques are critical for understanding and modelling the brain, and also for designing and interpreting experiments. Mathematical modelling is an essential tool to cut through the vast complexity of neurobiological systems and their many interacting elements.

The course teaches the central ideas, methods, and practices of modern computational neuroscience through a combination of lectures and hands-on project work. During the course’s mornings, distinguished international faculty deliver lectures on topics across the entire breadth of experimental and computational neuroscience. For the remainder of the time, students work on research projects in teams of 2 to 3 people under close supervision of expert tutors and faculty. Research projects are proposed by faculty before the course, and include the modeling of neurons, neural systems, and behavior, the analysis of state-of-the-art neural data (behavioral data, multi-electrode recordings, calcium imaging data, connectomics data, etc.), and the development of theories to explain experimental observations.

Course directors

Brent Doiron

Course Director

University of Chicago, US

Geffen

Maria Geffen

Course Director

University of Pennsylvania, US

Gjorgjieva

Julijana Gjorgjieva

Course Director

Max Planck Institute for Brain

Research, Germany

Joe Paton

Course Director

Champalimaud Research, Portugal

Keynote Speakers

Megan Carey – Champalimaud Research, Portugal
Alex Cayco-Gajic – École Normale Supérieure, France 
John Krakauer – Johns Hopkins University, USA
Gilles Laurent – Max Planck Institute for Brain Research, Germany 
Maté Lengyel – Cambridge University, UK 
Ashok Litwin-Kumar – Columbia University, USA
Christian Machens – Champalimaud Research, Portugal
Olivier Marre – Vision Institute, France 
Ken Miller – Columbia University, USA
Mala Murthy – Princeton Univerisity, USA
Srdjan Ostojic – École Normale Supérieure, France 
Anne-Marie Oswald – University of Pittsburgh, USA
Alfonso Renart – Champalimaud Research, Portugal
Nathalie Rochefort – University of Edinburgh, UK
Vanessa Ruta – The Rockfeller University, USA
Tim Vogels – IST, Austria

Course content

Projects

Project 1. Emergence of selectivity through the interplay of Hebbian and homeostatic plasticity in neuronal networks (Gjorgjieva)

Project 2. Neural circuits for the generation of locomotor behavior (Gjorgjieva)

Project 3. Analysis of multi-neuron spike time series data from the locust olfactory system (Laurent)

Project 4. Reinforcement learning as a model for decision making (Paton & Lloyd)

Project 5. Finding structure in natural behavior (Murthy)

Project 6. The SSN: Dynamic behavior, effects of adaptive and saturating mechanisms and of network noise (Miller & Doiron)

Project 7. Uncovering synaptic plasticity rules from experiments (Stein)

Project 8. Implementing linear, nonlinear, and chaotic computations in spike coding networks (Keemink)

Project 9.Teaching animals to respond without bias by teaching algorithms to find bias (Macke)

Project 10.Predicting responses of single neuron in vitro: Mechanistic vs LIF models (Gonçalves & Macke)

Project 11. The role of inhibitory neurons in sound adaptation (Geffen)

Project 12. The neuronal circuit for hearing under uncertainty (Geffen)

Preliminary programme

All days are structured with lectures in the morning and experimental learning & tutorials – followed by discussion – in the afternoon

Week 1

17-22 July

  • Arrival and Welcome reception

  • Introduction and Single-Neuron Dynamics

  • Statistical analysis of neural data

  • Network dynamics

  • Normative models

  • Physical Constraints on Computing

23-24 July

Social event and free time

Week 2

25-29 July

  • Sensory coding and receptive fields

  • Spatial coding and memory

  • Vision

  • Neural Circuits and Synaptic Plasticity

  • Map formation and self-organization

30-31 July

Social event and free time

Week 3

1-5 August

  • Balanced Networks & Efficient Population Coding

  • Dendritic Computations & Birdsong Production

  • Reinforcement learning

  • Project work and presentations

6 August

Departure

For more information on the course programme, you can visit the past course website.

Champalimaud Centre for the Unknown, Portugal

The Champalimaud Foundation is a private, non-profit organization, established in 2005 and dedicated to research excellence in biomedical science. Completed in 2010, the Champalimaud Centre for the Unknown is a state-of-the-art centre that houses the Champalimaud Clinical Centre and the Champalimaud Research, with its three parallel programs – the Champalimaud Neuroscience Programme, the Physiology and Cancer Programme, and the Experimental Clinical Research Programme.
Initially focused on a system and circuit approach to brain function and behavior, the Centre expanded to incorporate molecular and cell biological expertise. The Centre comprises 26 research groups (circa 400 researchers) leading independent curiosity-based research.

Facilities
The Centre provides Facilities dedicated for Training, some in their entirety, for use by the CAJAL Advanced Neuroscience Training Programme. These include the Teaching Laboratory, a fully equipped open lab space for 20-30 students that can be dynamically reconfigured to support a full range of neuroscience courses. It also overlooks, via floor to ceiling windows, a tropical garden and the river. The experimental spaces include: Imaging Lab: A dark-room containing a full size optical table is used for advanced imaging setups (two-photon microscopy, SPIM, etc.) and custom (course-designed) optical systems.

Registration

Fee : 2.500 € (includes tuition fee, accommodation and meals)

Pre-school fee: 400 €

This course has been rescheduled from 2020. The participants were selected in 2020. If some of them can’t attend, we will advertise a short call for applications on this page.

The CAJAL programme offers 4 stipends per course (waived registration fee, not including travel expenses). Please apply through the course online application form. In order to identify candidates in real need of a stipend, any grant applicant is encouraged to first request funds from their lab, institution or government.

Kindly note that if you benefited from a Cajal stipend in the past, you are no longer eligible to receive this kind of funding. However other types of funding (such as partial travel grants from sponsors) might be made available after the participants selection pro- cess, depending on the course.